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Anti-FOXO3 Polyclonal Antibody

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产品名称： Anti-FOXO3 Polyclonal Antibody

英文名称： Anti-FOXO3 Polyclonal Antibody

产品编号： K001577P

产品价格： null

产品产地：北京

品牌商标： solarbio

更新时间： 2025-02-07T13:54:15

使用范围： WB IHC IF

北京索莱宝科技有限公司

联系人 : 索莱宝-龚思雨
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产品详情

Anti-FOXO3 Polyclonal Antibody  
品牌：solarbio | 货号：K001577P





英文名称 Anti-FOXO3 Polyclonal Antibody
宿主 Rabbit
别名 1110048B16Rik;2010203A17Rik;C76856;FKHRL1;Fkhr2;Foxo3a
应用 WB IHC IF
稀释比例 WB 1:500-2000. IHC 1:50-200. IF 1:50-200.
交叉反应 Human Mouse Rat
蛋白分子量 90kDa
Gene ID 56484
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of mouse FOXO3
性状 液体
Public 
Immunogen 
Range Recombinant protein of mouse FOXO3
Subcellular 
Locations Cytoplasm Membrane Nucleus
Swiss Prot Q9WVH4
克隆类型 Polyclonal Antibody
背景资料 Forkhead box O-class (FOXO) transcription factors are 
mammalian homologue of DAF-16, a known lifespan 
regulator of Caenorhabditis elegans. FOXO transcription 
factors, such as FOXO1, FOXO3a, and FOXO4, have been 
linked to the regulation of cell cycle, apoptosis, DNA 
repair, oxidative stress, and metabolism. FOXO proteins 
are proposed to be dual regulated by Akt-mediated 
phosphorylation and Skp2-mediated ubiquitination, 
which are usually initiated by growth factors and 
cytokines. FOXO proteins are also activated by stress, 
which induces gene expression that contributes to cell 
cycle arrest, implicating FOXO proteins as tumor 
suppressors. Specifically, FOXO3a (FKHR-L1) is a 
transcriptional activator for apoptosis in the 
absence of survival factors, such as in neural cell death 
triggered by oxidative stress. In the presence of survival 
factors like IGF-1, AKT1/PKB phosphorylates on Thr-32 
and Ser-253. FOXO3a is inactivated when 
phosphorylated by AKT1 on Thr-32 and Ser-253.

英文名称	Anti-FOXO3 Polyclonal Antibody
宿主	Rabbit
别名	1110048B16Rik;2010203A17Rik;C76856;FKHRL1;Fkhr2;Foxo3a
应用	WB IHC IF
稀释比例	WB 1:500-2000. IHC 1:50-200. IF 1:50-200.
交叉反应	Human Mouse Rat
蛋白分子量	90kDa
Gene ID	56484
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG
免疫原	Recombinant protein of mouse FOXO3
性状	液体
Public Immunogen Range	Recombinant protein of mouse FOXO3
Subcellular Locations	Cytoplasm Membrane Nucleus
Swiss Prot	Q9WVH4
克隆类型	Polyclonal Antibody
背景资料	Forkhead box O-class (FOXO) transcription factors are mammalian homologue of DAF-16, a known lifespan regulator of Caenorhabditis elegans. FOXO transcription factors, such as FOXO1, FOXO3a, and FOXO4, have been linked to the regulation of cell cycle, apoptosis, DNA repair, oxidative stress, and metabolism. FOXO proteins are proposed to be dual regulated by Akt-mediated phosphorylation and Skp2-mediated ubiquitination, which are usually initiated by growth factors and cytokines. FOXO proteins are also activated by stress, which induces gene expression that contributes to cell cycle arrest, implicating FOXO proteins as tumor suppressors. Specifically, FOXO3a (FKHR-L1) is a transcriptional activator for apoptosis in the absence of survival factors, such as in neural cell death triggered by oxidative stress. In the presence of survival factors like IGF-1, AKT1/PKB phosphorylates on Thr-32 and Ser-253. FOXO3a is inactivated when phosphorylated by AKT1 on Thr-32 and Ser-253.