GABRA4 Pre-design Chimera RNAi
产品名称： GABRA4 Pre-design Chimera RNAi
英文名称： GABRA4 Pre-design Chimera RNAi
产品编号： H00002557-R01
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
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- Specification
- Product Description:
- Homo sapiens gamma-aminobutyric acid (GABA) A receptor, alpha 4 (GABRA4), mRNA.
- Reactivity:
- Human
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_000809
- Note:
- Position of the Chimera RNAi.
-
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 2557
- Gene Name:
- GABRA4
- Gene Alias:
- -
- Gene Description:
- gamma-aminobutyric acid (GABA) A receptor, alpha 4
- Omim ID:
- 137141
- Gene Ontology:
- Hyperlink
- Gene Summary:
- GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq
- Other Designations:
- gamma-aminobutyric acid A receptor, alpha 4
- Gene Pathway
- Related Disease
- Anorexia Nervosa
- Autistic Disorder
- Bipolar Disorder
- Bulimia
- Cardiovascular Diseases
- Diabetes Mellitus, Type 2
- Disease Models, Animal
- Dyskinesia, Drug-Induced
- Edema
- Genetic Predisposition to Disease
- Hypercholesterolemia
- Mental Retardation
- Psychotic Disorders
- Schizophrenia
- Schizophrenia
- Tobacco Use Disorder