ACO1 polyclonal antibody
产品名称： ACO1 polyclonal antibody
英文名称： ACO1 polyclonal antibody
产品编号： PAB18048
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of ACO1.
- Immunogen:
- A synthetic peptide corresponding to human ACO1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- This antibody is specific to ACO1.
- Form:
- Liquid
- Storage Buffer:
- In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Immunohistochemistry (1:50~1:100)
IELISA (1:20000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Expression of active iron regulatory factor from a full-length human cDNA by in vitro transcription/translation.
Hirling H, Emery-Goodman A, Thompson N, Neupert B, Seiser C, Kuhn LC.Nucleic Acids Res. 1992 Jan 11;20(1):33-9.
- 2.
- Homology between IRE-BP, a regulatory RNA-binding protein, aconitase, and isopropylmalate isomerase.
Hentze MW, Argos P.Nucleic Acids Res. 1991 Apr 25;19(8):1739-40.
- 3.
- Cloning of the cDNA encoding an RNA regulatory protein--the human iron-responsive element-binding protein.
Rouault TA, Tang CK, Kaptain S, Burgess WH, Haile DJ, Samaniego F, McBride OW, Harford JB, Klausner RD.Proc Natl Acad Sci U S A. 1990 Oct;87(20):7958-62.
- Application Image
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- enlarge
- Immunohistochemistry
- ELISA
- Entrez GeneID:
- 48
- Protein Accession#:
- P21399
- Gene Name:
- ACO1
- Gene Alias:
- ACONS,IREB1,IREBP,IREBP1,IRP1
- Gene Description:
- aconitase 1, soluble
- Omim ID:
- 100880
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes. [provided by RefSeq
- Other Designations:
- OTTHUMP00000021176,OTTHUMP00000021177,OTTHUMP00000045233,aconitase 1,aconitate hydratase,citrate hydro-lyase,ferritin repressor protein,iron regulatory protein 1,iron-responsive element binding protein 1
- Gene Pathway
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of alkaloids derived from terpenoid and polyketide
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Biosynthesis of terpenoids and steroids
- Citrate cycle (TCA cycle)
- Glyoxylate and dicarboxylate metabolism
- Metabolic pathways
- Reductive carboxylate cycle (CO2 fixation)